Juvenile dermatomyositis (JDM) is a rare, multisystemic, idiopathic vasculopathy mainly affecting the muscles and the skin.Gastrointestinal system, lungs, joints and heart may also be involved.Characteristic skin findings are heliotrope rash and Gottron papules but extensive skin involvement as large necrotic lesions are rarely reported.Calcinosis
Abstract Background Achieving climate neutrality in cities is a major challenge, especially in light of rapid urbanization and the urgent need to combat climate change.This paper explores the role of advanced computational methods in the transition of cities Switch Tray to climate neutrality, with a focus on energy supply and transportation systems
Wireless devices consume large amounts of energy during wireless communication.As the energy storage of battery is limited, improving energy efficiency has become an important approach to prolong the lifetime of devices.The IEEE 802.11 protocol supports the power save mode (PSM) in wireless local area networks (WLANs).However, the standard PSM cann
People with profound and multiple learning disabilities (PMLD) are some of the most marginalised in society and are perceived to lack agency.This paper contests such a narrative, presenting findings from an innovative project in Scotland, UK, Junior Fender exploring the impact of artists working collaboratively with people with PMLD and their forma
A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes.For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), Cdc48/p97 pulls polyubiquitinated, misfolded proteins out of the ER and